Medicinal Characteristics of Withania somnifera L. in Colorectal Cancer Management
نویسندگان
چکیده
Research into tumorigenic pathways can aid in the development of more efficient cancer therapies and provide insight physiological regulatory mechanisms employed by rapidly proliferating cells. Due to severe side effects chemotherapeutic medications, plant chemicals their analogues are now explored frequently for treatment prevention colorectal (CRC), opening stage new phytotherapeutic strategies that considered effective safe substitutes. Our study aimed evaluate medicinal properties Withania somnifera L. its safety applications CRC management. Important databases were rigorously searched relevant literature, only 68 full-text publications matched inclusion requirements from a massive collection 6421 titles abstracts. W. contains high concentration active plant-based compounds. The pharmacological activity our has been demonstrated exert antiproliferation, upregulation apoptosis, decrease oxidative stress, downregulation cyclooxygenase-2 (COX-2), induction targeted cytotoxic on cancerous cells, exertion both antiangiogenesis antimigratory effects. We advise further research before recommending clinical use identify optimal concentrations required elicit beneficial management humans, singly or combination.
منابع مشابه
Meiotic Studies in Withania somnifera (L.) Dunal.: A Threatened Medicinal Herb of Indian Thar Desert
Withania somnifera recently categorized as threatened plant of Rajasthan and known for its high medicinal value has been studied for existing genetic variations in four accessions collected from four different locations. From the present studies it is apparent that the gametic number of W. somnifera is n = 24 and 2n = 48. From the combined information generated by present author and earlier wor...
متن کاملIn Vitro Propagation of Withania somnifera (L.) Dunal.
Withania somnifera (L.) Dunal known as Ashwagandha is commonly used in traditional Indian medicine system. It possesses immense therapeutic value against a large number of ailments such as mental diseases, asthma, inflammation, arthritis, rheumatism, tuberculosis, and a variety of other diseases including cancer. The therapeutic potential of W. somnifera is due to the presence of secondary meta...
متن کاملOf withania somnifera pdf
Gate the properties of ashwagandha in an attempt to authenticate its use as a.Asgand consists of the roots of Withania somnifera which has various therapeutic actions such as. Withania somnifera Dunal belongs to the family solanaceae.Withania somnifera is a medicinal plant extends over a large area, from the.
متن کاملIn vitro withanolide production by Withania somnifera L. cultures.
In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2023
ISSN: ['1424-8247']
DOI: https://doi.org/10.3390/ph16070915